Samit Shah, PhD, MBA, RPh

Assistant Dean and Chair Biopharmaceutical Sciences and Associate Professor

Dr. Shah joins the KGI School of Pharmacy from South University School of Pharmacy (SUSOP), where he served as an associate professor in the Department of Pharmaceutical Sciences. He received several awards related to teaching effectiveness at SUSOP and played key roles on the Assessment, Curriculum, Technology and Admissions committees. His research in the area of chemical biology has been published in top journals such as Angewandte Chemie, Journal of the American Chemical Society, Nature Protocols and Nucleic Acids Research. His current research interests include the development of a novel siRNA delivery system that allows selective activation of RNAi in cancer cells and the study of metabolism-based drug-drug interactions. Dr. Shah earned a B.S. in pharmacy from North Gujarat University, a PhD in pharmaceutical sciences from the University of Missouri-Kansas City (UMKC), and an MBA from South University. He received post-doctoral training at the Massachusetts Institute of Technology (MIT). Dr. Shah is a licensed pharmacist in the states of Georgia and Washington and has worked as a PRN pharmacist and pharmacist-in-charge at Rite Aid Pharmacy and HealthQwest Clinic, respectively. As the assistant dean and chair of Biopharmaceutical Sciences, Dr. Shah has primary oversight of administrative functions for the biopharmaceutical sciences faculty and will take a leading role in developing innovative teaching, research and service programs for the School of Pharmacy.

Shah, S.; Cox, A.G.; Zdanowicz M.M. Student perceptions of the use of pre-recorded lecture modules and class exercises to enhance learning in a molecular biology course. Currents in Pharmacy Teaching and Learning. 2013, 5: 651-658.

Thomas, M.; Shah, S. New treatment options for acute edema attacks caused by hereditary angioedema. Am J Health Syst Pharm. 2011, 68: 2129-38.

Cox, A.G.; Shah, S. Pharmacognosy of the herbal medicine Hoodia Gordonii, a traditional appetite suppressant. Pharmacie Globale. 2011, 7: 10.

Jain, P.; Shah, S.; Friedman, S.H. Patterning of gene expression using new photolabile groups applied to Light Activated RNAi. J Am Chem Soc. 2011, 133: 440-446.

Shah, S.; Lynch, L.M.; Macias-Moriarity, L. Crossword puzzles as a tool to enhance learning about anti-ulcer agents. Am J Pharm Educ. 2010, 74: 117.

Shah, S.; Jain, P.; Kala, A.; Karunakaran, D.; Friedman, S.H. Light activated RNA interference using double stranded siRNA precursors modified using a remarkable regiospecificity of diazo-based photo labile groups., Nucleic Acids Research.: 2009, 37: 4508-4517.

Baruah, H.; Puthenveetil, S.; Choi, Y.C.; Shah, S; Ting, A.Y. An engineered aryl azide ligase for site-specific mapping of protein-protein interactions via crosslinking, Angewandte Chemie Int. Ed. Eng.: 2008, 47: 7018-7021.

Shah, S.; Friedman, S.H.  An ESI-MS method for the characterization of oligonucleotides used for RNAi and other biological applications, Nature Protocols.: 2008, 3: 351-356.

Shah, S.; Friedman, S.H.  Tolerance of siRNA for 5' anti-sense phosphate modifications, Oligonucleotides.: 2007, 17: 43.

Shah, S.; Rangarajan, S.; Friedman, S.H.  Light Activated RNA Interference, Angewandte Chemie Int. Ed. Eng.: 2005, 44: 1328-1332.

siRNAs are being developed as therapeutic agents because of their ability to silence gene expression in a sequence-specific manner. Nuclease sensitivity, non-specific immune stimulation and lack of efficient and specific delivery serve as major impediments blocking the progression of siRNAs from the lab to the clinic. We are interested in developing a novel siRNA delivery system that addresses some of these obstacles by allowing selective activation of RNA interference within diseased cells.

Cytochrome P450s (CYPs) play a key role in drug clearance and are responsible for a number of drug-drug interactions. One of our goals is to identify drug-drug interactions caused due to metabolic inactivation of CYP isoforms using in vitro studies.

Samit Shah

Contact Information

Samit Shah, PhD, MBA, RPh
Location: Building 517, Room B143
Phone: (909) 607-0131
Fax: (909) 607-9826
samit_shah[at symbol]kgi.edu